SEA0400 CAS:223104-29-8

SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger(NCX)that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes,and microglia with IC50 of 33 nM,5.0nM and 8.3 nM,respectively.SEA0400 prevents sodium nitroprusside(SNP)from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species(ROS)in an extracellular Ca(2+)-dependent manner.

msds---SEA0400